品牌簡介

HansaBioMed’s purified lyophilized exosomes are isolated through a combination of ultracentrifugation and microfiltration procedures. Exosomes are subsequently quantified and validated for overall protein content and particle number by Nanoparticles Tracking Analysis (NTA, NanoSight). Lyophilization does not alter the stability of exosome proteins and nucleic acids, in comparison to other storage methods, including storage of fresh exosomes at -20°C. Lyophilized exosomes are easy to ship and stable for long term storage (up to 36 months).
Exosomes are small endosome derived lipid nanoparticles (50-120 nm) actively secreted by exocytosis by most living cells. Exosome release occurs either constitutively or upon induction, under both normal and pathological conditions, in a dynamic, regulated and functionally relevant manner. Both amount and molecular composition of released exosomes depend on the state of a parent cell. Exosomes have been isolated from diverse cell lines (hematopoietic cells, tumor lines, primary cultures, virus infected cells) as well as from biological fluids in particular blood (e.g. serum and plasma from cancer patients) and other body fluids (bronchoalveolar lavage fluid, pleural effusions, synovial fluid, urine, amniotic fluid, semen, saliva etc). Exosomes have pleiotropic physiological and pathological functions and an emerging role in diverse pathological conditions such as cancer, infectious and neurodegenerative diseases.